Medical calculators

Loading Dose

Vd-based loading

For education. Check every result.

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How it is calculated

Loading Dose = Target Concentration × Vd × Weight, for an IV dose of the active drug. Divide by bioavailability (F) for an oral dose and by the salt fraction (S) where it applies. It reaches the target concentration quickly; holding it there is the maintenance dose, and multi-compartment drugs such as digoxin take hours to distribute.

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The one-off dose needed to fill the body's volume of distribution and reach a target concentration quickly.

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