Lab reference

UGT1A1*28

Pre-Treatment

For education. Check every result.

Anatium is a study resource, not medical advice. Nothing here is a diagnosis, a prescription or a substitute for a clinician who has seen the patient. Check every number against a current local protocol before it touches anyone, and never act on a result you cannot reproduce yourself.

Reference range

RangeReported as genotype

About

A genotype affecting irinotecan clearance, checked before treatment because the *28 variant raises the risk of severe neutropenia and diarrhoea.

When it is low

Homozygous *28: reduced SN-38 clearance, so irinotecan causes more neutropenia and diarrhoea - reduce the dose

When it is high

Wild type: standard irinotecan dosing

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